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SYNGR1 Rabbit anti-Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA11044

Catalog No. PA11044

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PA1-1044 detects Synaptogyrin 1 in rat and mouse samples. PA1-1044 has been successfully used in Western blot procedures. By Western blot, this antibody detects a ~25.5 kDa protein representing Synaptogyrin 1 in rat and mouse brain tissue samples. The PA1-1044 immunogen is a synthetic peptide corresponding to residues D(187) P S Q D S S M P Y A P Y V E P(202) of rat Synaptogyrin 1. This sequence is conserved in mouse and human. The PA1-1044 immunizing peptide (Cat. No. PEP-280) is available for use in neutralization and control experiments.

Synaptogyrins comprise a family of tyrosine-phosphorylated proteins with two neuronal (synaptogyrins 1 and 3) isoforms. Previous studies have indicated that synaptogyrins are involved in the regulation of neurotransmitter release. Synaptogyrin 1 is an integral membrane protein ubiquitously expressed in the nervous system. Synaptogyrin has four transmembrane domains and an extended cytoplasmic tail but it is not glycosylated. Synaptogyrin 1 is a tyrosine-phosphorylated by c-src and possibly other tyrosine kinases. The function of Synaptogyrin 1 is not well understood, but it may be a useful marker for nerve terminals and diagnosing neuroendocrine tumors.

Abbreviations: AP=Affinity Purification, ChIP=Chromatin IP, CM=Confocal Microscopy, DB=Dot Blot, EIA=ELISA, EM=Electron Microscopy, FC=Flow Cytometry, GS=Gel Supershift, IC=Immunocytochemistry, IF=Immunofluorescence, IH=Immunohistology/Immunohistochemistry, IP=Immunoprecipitation, IPK=IP Kinase Assay, KA=Kinase Assay, NEUT=Neutralization, PIA=Peptide Inhibition Assay, RIA=Radioimmunossay, TCA=T Cell Activation, WB=Western Blotting, Species: Am=Amphibian, Av=Avian, B=Bovine, Ca=Cat ,Ck=Chicken, D=Dog, Dr=Deer, Ds=Drosophila, El=Elk, Fg=Frog, Fs=Fish, Ft=Ferret, G=Goat, Gp=Guinea Pig, H=Horse, Hm=Hamster, Hu=Human, K=Kangaroo, Ms=Mouse, Nhp=Non-Human Primate, O=Ovine, P=Porcine, Rb=Rabbit, Rp=Reptile, Rt=Rat, Ys=Yeast, Xn=Xenopus, (wk)=cross reacts weakly



Synthetic peptide corresponding to residues D(187) P S Q D S S M P Y A P Y V E P(202) of rat Synaptogyrin 1.
Antigen affinity chromatography
Mouse, Rat
Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
O55100, Q62876
100 μg
-20° C, Avoid Freeze/Thaw Cycles
20972, 29205
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