Synaptotagmin 1 Sheep anti-Human, Polyclonal, Invitrogen
Sheep Polyclonal Antibody
Manufacturer: Invitrogen OSS00063G
Glycerol (1:1) may be added for additional stability. Reconstitute in 500 µL of sterile water.Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein that is widely expressed throughout the CNS and is generally thought to act as the Ca2+ sensor in the regulation of exocytosis and neurotransmitter release. Studies indicate that synaptotagmin’s Ca2+ mediated binding of SNAP25 is essential for the Ca2+ dependent triggering of membrane. It has been demonstrated that discrete residues within the c(2)b binding domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size. Synaptotagmin 1 may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Further, Synaptotagmin 1 binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has been reported. Synaptotagmin 1 can also bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Diseases associated with the dysfunction of Synaptotagmin 1 include food-borne botulism and infant botulism.
|A synthetic peptide from human Synaptotagmin-1 (Synaptotagmin I) conjugated to an immunogenic carrier protein was used as the immunogen|
|Ammonium sulfate precipitation|
|Immunohistochemistry, Western Blot|
|Antibody with no preservative|
|Synaptotagmin-1, Synaptotagmin I, SytI, p65, SVP65|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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