Synphilin 1 Rabbit anti-Human, Rat, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA118270
PA1-18270 detects Synphilin-1 from human and rat samples. PA1-18270 has been successfully used in immunohistochemistry and Western blot procedures. The PA1-18270 immunogen is a synthetic peptide corresponding to residues C A S K G K N K A A of human synphilin-1a, conjugated to KLH. After reconstitution keep aliquots at -20°C for a higher stability, and at 4°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles. Reconstitute with 100 µL of distilled water. Centrifuge to remove any insoluble material.Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of SNCAIP have been linked to Parkinson disease. The amino acid sequence of synphilin-1 shares a high level of identity with its human counterpart, particularly in regions containing ankyrin-like motifs and the coiled-coil domain. Expression pattern of synphilin-1 in tissues is similar in both mouse and human. Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and also Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1.
|whole serum with no preservative|
|Alpha-synuclein-interacting protein, SNCAIP|
|Immunohistochemistry, Western Blot|
|Synthetic peptide corresponding to residues C A S K G K N K A A of human synphilin-1a conjugated to KLH.|
|-20° C, Avoid Freeze/Thaw Cycles|
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