Synphilin 1 Rabbit anti-Human, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA118270
PA1-18270 detects Synphilin-1 from human and rat samples. PA1-18270 has been successfully used in immunohistochemistry and Western blot procedures. The PA1-18270 immunogen is a synthetic peptide corresponding to residues C A S K G K N K A A of human synphilin-1a, conjugated to KLH. After reconstitution keep aliquots at -20°C for a higher stability, and at 4°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles. Reconstitute with 100 µL of distilled water. Centrifuge to remove any insoluble material.Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of SNCAIP have been linked to Parkinson disease. The amino acid sequence of synphilin-1 shares a high level of identity with its human counterpart, particularly in regions containing ankyrin-like motifs and the coiled-coil domain. Expression pattern of synphilin-1 in tissues is similar in both mouse and human. Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and also Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1.
|whole serum with no preservative|
|Alpha-synuclein-interacting protein, SNCAIP|
|Immunohistochemistry, Western Blot|
|Synthetic peptide corresponding to residues C A S K G K N K A A of human synphilin-1a conjugated to KLH.|
|-20° C, Avoid Freeze/Thaw Cycles|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok