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SYNPO2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA521055

Catalog No. PIPA521055


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Description

Description

A suggested positive control is human skeletal muscle tissue lysate. PA5-21055 can be used with blocking peptide PEP-1169.

SYNPO2 was initially identified as myopodin, a member of the synaptopodin family that contains one PPXY motif and multiple PXXP motifs. It colocalizes with alpha-actinin and is found at the Z-disc and during stress conditions will translocate to the nucleus, suggesting that it is part of signaling pathways in addition to its function as a structural protein. SYNPO2 has been shown to bind to calmodulin, alpha-actinin, and smooth muscle myosin and will stimulate actin polymerization in a calmodulin dependent manner, consistent with its proposed role in organizing the cytoskeleton. While deletion of SYNPO2 has been reported to be highly correlated with the invasiveness of prostate cancers, other reports suggest that down-regulation of SYNPO2 reduces the invasiveness and motility of prostate cancer cells.
Specifications

Specifications

SYNPO2
Polyclonal
Unconjugated
SYNPO2
Liquid
SYNPO2
A 20 amino acid peptide near the amino terminus of human SYNPO2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9UMS6, Q91YE8
genethonin 2; genethonin-2; myopodin; synaptopodin-2
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
118449, 171024
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