anti-Synuclein, α Ab-4; Polyclonal; Millipore™ (Chemicon™)

Manufacturer: EMD Millipore AB5038DEL

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Catalog No. 50-173-656


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    Antigen Synuclein, α Ab-4
    Conjugate Unlabeled
    Cross Reactivity Human,Rat
    Format Serum
    Host Species Rabbit
    Immunogen Human α-synuclein residues 111-131 coupled to KLH. The peptide sHuence is N-GILEDMPVDPDNEAYEMPSEEC-C.
    Quantity 50μL
    Regulatory Status RUO
    Research Discipline Neuroscience
    Primary or Secondary Primary
    Monoclonal or Polyclonal Polyclonal

    α -Synuclein is a small (140-amino acid) cytoplasmic protein of unclear function that is enriched in presynaptic terminals and is the precursor protein of a nonamyloid β component of senile plaques in Alzeheimer's Disease (AD). α -Synuclein is located predominantly in the presynaptic nerve terminals in the brain but is also found in low concentrations in all tissues except liver. Recent studies have shown that abnormal aggregation and accumulation of synaptic proteins, including alpha-Synuclein might be associated with plaque formation in AD and seems to be a major component of Lewy bodies in dementia with Lewy bodies (DLB). It has also been identified in the Glial Cytoplasmic Inclusions (GCIs) found in Multiple System Atrophy (MSA).

    Immunocytochemistry, Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blotting

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