TANK Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA525754
DescriptionTANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-kappa-B. This activation of NF-kappa-B occurs through an association with the kinases IKK-iota and TBK1. More recently, it was shown that these proteins can then form a complex with NEMO, a protein that regulates the activity of the Ikappa-B complex. This suggests that in addition to the possibility that TBK1 and IKK-iota activate the IKKs, the association with the IKK complex may help these kinases modulate other functions, such as the transactivation potential of NF-kappa-B proteins. At least two isoforms of TANK are known to exist.
|KLH conjugated synthetic peptide between 88-114 amino acids from the central region of human TANK|
|Antigen Affinity Chromatography, Protein A|
|Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.09% sodium azide|
|I-TRAF, TRAF2, TRAF family member-associated NF-kappa-B activator, TRAF-interacting protein|
|-20° C, Avoid Freeze/Thaw Cycles|
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