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TDP-43 Rabbit anti-Chicken, Human, Mouse, Non-human primate, Xenopus laevis, Zebrafish, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA116996
Suggested positive control: Hela whole cell extract, antigen standard for TARDBP (transient overexpression lysate).The HIV1 virus gives rise to acquired immunodeficiency syndrome (AIDS). HIV1 contains an RNA genome which produces chromosomally integrated DNA during cellular replication. Gene activation of HIV1 by the transactivator Tat requires an RNA regulatory element TAR which is located downstream of the transcription initiation site. TARDBP is a transcriptional repressor that binds to the chromosomally integrated TAR DNA, preventing HIV1 expression. Additionally, this protein regulates alternative splicing of the CTFR gene, a similar pseudogene on chromosoome 20. TARDBP has also been recently been shown to abnormally accumulate in the post-mortem brain tissue of individuals diagnosed with ALS (Amyotrophic Lateral Sclerosis) and FTD (Frontal Temporal Dementia). This long-awaited conncection between these two diseases provides an explanation for the observed clinical overlap.
|Synthetic peptide corresponding to C terminal region within residues 350-414 of the human TARDBP protein.|
|Antigen affinity chromatography|
|Chicken, Human, Mouse, Non-human primate, Xenopus laevis, Zebrafish|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.05% sodium azide|
|Q5ZLN5, Q13148, Q921F2|
|TARD binding protein , TAR DNA-binding protein 43 , TDP-43 , TDP43|
|4° C, do not freeze|
|230908, 23435, 325052, 380329, 419453|
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