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Tau Mouse anti-Bovine, Human, Mouse, Ovine, Rat, Clone: TAU-5, Invitrogen™ Non-distribution product as customer accommodation. Available on GSA/VA Contract for Federal Government customers only.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen AHB0042

Catalog No. AHB0042


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Description

Description

Tau is a neuronal microtubule-associated protein found predomitly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer ft.s diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclindependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick ft.s disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

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Specifications

Specifications

Tau
Monoclonal
Unconjugated
MAPT
Liquid
MAPT
Purified bovine microtubule-associated proteins.
Purified
RUO
Antibody
Monoclonal
Bovine, Human, Mouse, Ovine, Rat
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
TAU-5
PBS with 15mM sodium azide; pH 7.4
P29172, P10636, P10637, P19332
MAPT, Microtubule-associated protein tau, MTBT1, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, Tau5
Mouse
IgG1
100 μg
-20°C
Primary
17762, 281296, 29477, 4137
SDS
Documents
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