TBK1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA515053

Catalog No. PIPA515053

Description

This antibody is predicted to react with mouse and Xenopus based on sequence homology.

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. TKB is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.

Specifications

• Antigen: TBK1
• Classification: Polyclonal
• Gene: TBK1
• Gene Alias: NAK, Serine/threonine-protein kinase TBK1, TANK-binding kinase 1, T2K, NF-kappa-B-activating kinase, TBK1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 29110
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Conjugate: Unconjugated
• Gene Accession No.: Q9UHD2
• Gene Symbols: TBK1
• Immunogen: KLH conjugated synthetic peptide between 150-181 amino acids from human TBK
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG