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TBLR1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141271

Catalog No. 01-675-617


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Description

Description

This antibody may cross-react with mouse and rat TBLR1, based on sequence homology. Suggested positive control: human brain tissue, human brain protein.

Chromatin organization plays a fundamental role in regulating transcription in eukaryotic cells. The nuclear receptor corepressor (N-CoR) and silencing mediator of retinoid and thyroid homone receptors (SMRT) play a role in diverse transcriptional repression pathways. N-CoR and SMRT each exist in large protein complexes, and are thought to mediate repression, at least in part, by their ability to recruit histone deacetylases to generate repressive chromatin. HDAC3 is the main HDAC that associates with N-CoR and SMRT complexes, and its presence is thought to be essential for repression. TBLR1 is a WD-40 repeat protein that also associates with N-CoR and SMRT complexes. Although TBLR1 is thought to be a core component of both the N-CoR and SMRT complexes, its role in these complexes remains to be elucidated.
Specifications

Specifications

TBLR1
Polyclonal
Unconjugated
TBL1XR1
Liquid
TBL1XR1
Synthetic peptide corresponding to residues 200-250 of human TBLR1.
Protein G
RUO
Antibody
Polyclonal
Human
Western Blot
0.5 mg/mL
PBS with 0.2% gelatin and 0.05% sodium azide
Q9BZK7
C21, DC42, FLJ12894, IRA1, TBLR1
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
79718
Documents
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