TC10 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA11061
TC10 has been classified as a member of the Rho family of GTPases and possesses characteristics most closely related to Cdc42. This family of proteins regulates a wide variety of cellular activity including cytoskeletal rearrangements, motility, proliferation and apoptosis. TC10 is predominately localized to the cell membrane and TC10 mRNA was most highly expressed in heart and skeletal muscle.Recent studies with TC10 mutations have demonstrated that TC10 is responsible for the activation of c-jun amino terminal kinase, the activation of serum response factor-dependent transcription, and the formation of long filopodia. In other studies, TC10 interacts with a similar subset of effectors as Cdc42, but does not react with WASP, MLK3, or ACK-1.PA1-1061 detects human and mouse TC10 protein in transfected cell samples and endogenous levels in tissue extracts. PA1-1061 is specific for isotype TC10a and demonstrates slight cross-reactivity with TC10b.PA1-1061 has successfully been used in immunoprecipitation and Western blot procedures. By Western blot, this antibody detects an ~24kDa protein representing TC10 in transfected COS cells and a non-specific, unidentified band at ~50 kDa.The PA1-1061 immunogen is a synthetic peptide corresponding D(136) P K T L A R L N D M K E K P I C(152) from human TC10. This peptide (Cat. # PEP-219) is available for use in neutralization and control experiments.
|Synthetic peptide corresponding D(136) P K T L A R L N D M K E K P I C(152) from human TC10.|
|Antigen affinity chromatography|
|Immunoprecipitation, Western Blot|
|PBS with 1mg/mL BSA and 0.05% sodium azide|
|ARHQ, RASL7A, TC10, TC10A|
|-20° C, Avoid Freeze/Thaw Cycles|
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