TCF3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520900
A suggested positive control is human brain tissue lysate. PA5-20900 can be used with blocking peptide PEP-1014.The TCF3 gene, also called E2A, encodes two basic helix-loop-helix (bHLH) transcription factors, E12 and E47, through alternative splicing. These transcription factors are involved in mediating canonical Wnt signaling, which is very important in a diverse array of cellular functions such as stem cell proliferation, self-renewal, activation, fate determination, differentiation and aging and senescence. They bind beta-catenin and can act as transcriptional activators or repressors for Wnt target genes, and have been shown to regulate specific target genes during CNS development downstream of Wnt signaling. TCF3/Lef complexes are also known to play key roles in controlling cell fate lineages in multipotent skin stem cells.
|A 17 amino acid peptide near the amino terminus of human TCF3.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|P15923, P15806, P21677|
|E2A, E47, ITF1, TCF-3, VDIR, bHLHb21; VDR interacting repressor; class B basic helix-loop-helix protein 21; helix-loop-helix protein HE47; immunoglobulin transcription factor 1; kappa-E2-binding factor; negative vitamin D response element-binding protein; transcription factor E2-alpha; transcription factor ITF-1; vitamin D receptor-interacting repressor|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|171046, 21423, 6929|
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