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ARHGEF17 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520440

Catalog No. PIPA520440


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Description

Description

A suggested positive control is Jurkat cell lysate. PA5-20440 can be used with blocking peptide PEP-0557.

Rho GTPases, which are activated by specific guanine-nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 is a Rho-specific GEF with novel structural and regulatory properties and predomit expression in the heart. It couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful targets therapeutically.
Specifications

Specifications

ARHGEF17
Polyclonal
Unconjugated
ARHGEF17
Liquid
ARHGEF17
An 18 amino acid peptide near the center of human TEM4.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q96PE2
P164RHOGEF, TEM4, p164-RhoGEF; 164 kDa Rho-specific guanine-nucleotide exchange factor; Rho-specific guanine-nucleotide exchange factor 164 kDa; rho guanine nucleotide exchange factor 17; tumor endothelial marker 4
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
9828
Documents
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