ARHGEF17 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520440
A suggested positive control is Jurkat cell lysate. PA5-20440 can be used with blocking peptide PEP-0557.Rho GTPases, which are activated by specific guanine-nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 is a Rho-specific GEF with novel structural and regulatory properties and predomit expression in the heart. It couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful targets therapeutically.
|An 18 amino acid peptide near the center of human TEM4.|
|Antigen affinity chromatography|
|Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|P164RHOGEF, TEM4, p164-RhoGEF; 164 kDa Rho-specific guanine-nucleotide exchange factor; Rho-specific guanine-nucleotide exchange factor 164 kDa; rho guanine nucleotide exchange factor 17; tumor endothelial marker 4|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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