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TGF beta-1 Mouse anti-Mouse, Clone: 9016, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523702

Catalog No. PIMA523702

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

In sandwich ELISAs, less than 2% cross-reactivity with Recombinant human (rh) TGF- beta 3 and Recombinant amphibian TGF- beta 5 and no cross-reactivity with Recombinant porcine TGF-beta 2 or rhTGF-beta 2 is observed. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP. TGF beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types. Many cells have TGF beta receptors, and the protein positively and negatively regulates many other growth factors. TGF beta-1 is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGF beta-1 homodimer. The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis.
Specifications

Specifications

TGF beta-1
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
P04202
TGFB, TGFb-1, DPD1, Transforming Growth Factor, Transforming Growth Factor Beta-1, TGF-beta-1, CED
Mouse
IgG1
500 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
21803
ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Neutralization, Western Blot
9016
Unconjugated
Tgfb1
Lyophilized
TGFB1
CHO-derived recombit TGF-beta 1 and latent TGF-beta 1
Protein A/G
RUO
Antibody
Monoclonal
Mouse
Documents
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