TGF beta-1 Mouse anti-Mouse, Clone: 9016, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA523702
In sandwich ELISAs, less than 2% cross-reactivity with Recombinant human (rh) TGF- beta 3 and Recombinant amphibian TGF- beta 5 and no cross-reactivity with Recombinant porcine TGF-beta 2 or rhTGF-beta 2 is observed. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP. TGF beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types. Many cells have TGF beta receptors, and the protein positively and negatively regulates many other growth factors. TGF beta-1 is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGF beta-1 homodimer. The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis.
|PBS with 5% trehalose and No Preservative|
|TGFB, TGFb-1, DPD1, Transforming Growth Factor, Transforming Growth Factor Beta-1, TGF-beta-1, CED|
|-20° C, Avoid Freeze/Thaw Cycles|
|ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Neutralization, Western Blot|
|CHO-derived recombit TGF-beta 1 and latent TGF-beta 1|
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