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TGF beta-1 Chicken anti-Human, Mouse, Porcine, Rat, Polyclonal, Invitrogen™

Chicken Polyclonal Antibody

Manufacturer:  Invitrogen PA19574

Catalog No. 01-674-450


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Description

Description

PA1-9574 detects TGFb1 in human, mouse and rat samples. PA1-9574 has been successfully used in Western blot, Immunohistochemistry, Immunocytochemistry, and ELISA procedures. By Western blot, PA1-9574 detects a 25 kDa protein representing TGFb1. PA1-9574 immunogen is a peptide based on mouse and human TGFb1 protein (RKPKVEQLSNMIVRS). Store 4c for 1 week and -20c for long term storage.

TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP. TGF beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types. Many cells have TGF beta receptors, and the protein positively and negatively regulates many other growth factors. TGF beta-1 is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGF beta-1 homodimer. The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis.
Specifications

Specifications

TGF beta-1
Polyclonal
Unconjugated
TGFB1
Liquid
TGFB1
Peptide based on mouse and human TGFß1 protein (RKPKVEQLSNMIVRS).
Affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Porcine, Rat
ELISA, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P01137, P04202, P07200, P17246
CED, DPD1, TGFB
Chicken
IgY
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
21803, 397078, 59086, 7040
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