THEMIS Mouse anti-Human, Brilliant Violet 421, Clone: Q13-1103, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 563721
The Q13-1103 monoclonal antibody specifically binds to human THEMIS (Thymocyte-expressed molecule involved in selection). The human THEMIS gene encodes a 73-kDa signaling protein that is also known as thymocyte selection pathway associated (TSEPA), signaling phosphoprotein specific for T cells (SPOT) and GRB2-associated protein (GASP). The homologous mouse protein is encoded by the Themis gene. THEMIS mRNA is detected in the thymus, lymph nodes, spleen but not in the bone marrow or nonlymphoid tissues. It is expressed by all thymocytes including double- (high levels) and single-positive αβ T cells, γδ T cells and peripheral T cells (low levels) but not by B cells and NK cells. THEMIS plays a central role in T cell development including positive and negative selection processes in the thymus. It is involved in TCR signaling and gets phosphorylated quickly after TCR stimulation. In the mouse system, -deficient thymocytes showed impaired selection that lead to the production of fewer mature thymocytes. The Q13-1103 antibody crossreacted with mouse Themis in Western blot testing of cellular lysates but did not crossreact when tested by immunofluorescent staining and flow cytometric analysis of cells.
|TSEPA; THMS1; C6orf190; C6orf207; SPOT; GASP; GRB2-associated protein|
|Human THEMIS Recombinant Protein|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Brilliant Violet 421|
|Aqueous buffered solution containing BSA and ≤0.09% sodium azide.|
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