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Thomsen-Friedenreich Antigen Mouse anti-Human, Clone: A68-B/A11, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA135817

Catalog No. 01-672-320


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Description

Description

The Thomsen-Fridenreich antigen acts as an oncofetal antigen, with low expression in normal adult tissues but increasing to fetal levels of expression in hyperplasia or maligcy. It is considered as a pan-carcinoma marker. This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined.
Specifications

Specifications

Thomsen-Friedenreich Antigen
Monoclonal
100 μg/mL
PBS with 0.05% sodium azide
TFA
Neuraminidase-treated human red blood cells.
Purified
RUO
Antibody
Monoclonal
ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Inhibition Assays
A68-B/A11
Unconjugated
Liquid
Mouse
IgM
100 μg
4° C
Primary
Human
Documents
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