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Thrombin Receptor/PAR1 Mouse, Unlabeled, Clone: 14, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611523

Catalog No. BDB611523


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Description

Description

Thrombin is a serine protease that regulates the activity of many cell types including the activation of platelets after vascular injury. Thrombin functions are mediated by G-protein-coupled protease-activated receptors that are homologous to substance P and thyrotropin receptors. Thrombin receptors (PAR1, PAR3, and PAR4) are seven transmembrane domain proteins with large N-terminal exodomains that contain a thrombin cleavage site (LDPR/S). Thrombin binds to the exodomain and cleaves the peptide bond between Arg-41 and Ser-42. This unmasks a new N-terminus with the sequence SFLLRN that acts as a tethered ligand. SFLLRN binds to the body of the thrombin receptor leading to irreversable activation. Both phosphorylation of the thrombin receptor and internalization may uncouple downstream signaling. PAR1 protein is expressed in vascular endothelial cells, smooth muscle cells, and macrophages, while PAR1 mRNA is expressed at higher levels in neonatal rat brain and lower levels in skeletal muscle, liver, and kidney. Thus, G-protein signaling via thrombin receptors, like PAR1, may be important for a diverse array of cellular functions, such as platelet activation and neural development.

Host Species: Mouse
Clone: 14
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Thrombin Receptor/PAR1 aa. 33-153
Formula Weight [Chemical]: 47kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

Thrombin Receptor/PAR1
14
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
Protease Activated Receptor-1 (PAR1)
Affinity Purified
Human Thrombin Receptor/PAR1 aa. 33-153
150μg
Cell Biology
Primary
Human, Murine
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