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Thymidylate Synthase Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527867

Catalog No. PIPA527867


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Description

Description

PA5-27867 targets Thymidylate synthetase in IHC (P) and WB applications and shows reactivity with Human, rat, and mouse samples. The PA5-27867 immunogen is recombit fragment corresponding to a region within amino acids 35 and 313 of Human Thymidylate synthetase. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.
Specifications

Specifications

Thymidylate Synthase
Polyclonal
Unconjugated
TYMS
Liquid
TYMS
Recombit fragment corresponding to a region within amino acids 35 and 313 of Human Thymidylate synthetase
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
1 mg/mL
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
P04818, P07607, P45352
HST422, TMS, TS, TSase, thymidylate synthase
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
22171, 29261, 7298
Documents
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