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THRA Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1216

Catalog No. PA1-216

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PA1-216 detects the thyroid hormone receptor alpha 2 from human and mouse samples. PA1-216 has been successfully used in Western blot, ICC/IF and immunohistochemistry (paraffin) procedures. By Western blot, this antibody detects bands at ~58 kDa representing Tra2 in mouse tissue. This antibody also detects a ~43 kDa protein which is believed to be non-specific. The PA1-216 immunizing peptide corresponds to amino acid residues 455-469 from rat thyroid hormone receptor alpha 2.

Thyroid hormone receptor alpha 2 protein mediates the function of thyroid hormone. There are three forms of the thyroid hormone receptors known as alpha-1, alpha-2 and beta. Studies have suggested that these three forms of the thyroid hormone receptor are abundant in most tissues; however, none of these three thyroid hormone receptors were abundant in the liver, which is the major thyroid hormone-responsive organ. Therefore another type of thyroid hormone receptor is believed to be present in liver. The identification of the several types of thyroid hormone receptor may explain the normal variation in thyroid hormone responsiveness of various organs and the selective tissue abnormalities found in the thyroid hormone resistance syndromes.

Abbreviations: AP=Affinity Purification, ChIP=Chromatin IP, CM=Confocal Microscopy, DB=Dot Blot, EIA=ELISA, EM=Electron Microscopy, FC=Flow Cytometry, GS=Gel Supershift, IC=Immunocytochemistry, IF=Immunofluorescence, IH=Immunohistology/Immunohistochemistry, IP=Immunoprecipitation, IPK=IP Kinase Assay, KA=Kinase Assay, NEUT=Neutralization, PIA=Peptide Inhibition Assay, RIA=Radioimmunossay, TCA=T Cell Activation, WB=Western Blotting, Species: Am=Amphibian, Av=Avian, B=Bovine, Ca=Cat ,Ck=Chicken, D=Dog, Dr=Deer, Ds=Drosophila, El=Elk, Fg=Frog, Fs=Fish, Ft=Ferret, G=Goat, Gp=Guinea Pig, H=Horse, Hm=Hamster, Hu=Human, K=Kangaroo, Ms=Mouse, Nhp=Non-Human Primate, O=Ovine, P=Porcine, Rb=Rabbit, Rp=Reptile, Rt=Rat, Ys=Yeast, Xn=Xenopus, (wk)=cross reacts weakly



Synthetic Peptide: S(455) R A V C G E D D S S E A S S(469)
Antigen affinity chromatography
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
P10827, P63058
TR Alpha 2, TR
200 μg
-20° C, Avoid Freeze/Thaw Cycles
21833, 7067
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