THRB Rabbit anti-Human, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA138763
This antibody is predicted to react with canine, mouse, porcine and rabbit based on sequence homology. Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 10 min at room temperature. A suggested positive control is thyroid tissue.Thyroid hormone receptors (TRs) are ligand dependent members of the steroid/retinoic acid superfamily of transcription factors. The two genes encoding TRs identified to date, TRalpha and TRBeta, have been mapped to human chromosomes 17 and 3, respectively. TRs bind to thyroid hormone response elements (TREs) with half site binding motifs in the orientation of palindromes, direct repeats, or inverted palindromes. The affinities of binding are both variable and influenced differentially by 3,5,3’-triiodo-L-thyronine (T-3).
|PBS with 1% BSA and <0.1% sodium azide; pH 7.6|
|C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2, nuclear receptor subfamily 1 group A member 2, oncogene ERBA2, thyroid hormone nuclear receptor beta variant 1, thyroid hormone receptor beta, thyroid hormone receptor, beta erythroblastic leukemia viral v-erb-a oncogene homolog 2, avian|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Synthetic peptide derived from N-terminus of human THR-beta protein|
|Antigen affinity chromatography|
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