TIGAR Rabbit anti-Canine, Human, Non-human primate, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA141487
DescriptionTIGAR is a p53-inducible protein that functions to regulate glycolysis and protect against oxidative stress and is part of the p53 tumor suppressor pathway. It encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2, 6-bisphosphate. TIGAR functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Overexpression of TIGAR in mouse and human cells resulted in inhibition of glycolysis, as well as a decrease in intracellular reactive oxygen species (ROS) and provides some protection from DNA damage-induced apoptosis in a cell type-specific manner.
|Synthetic peptide corresponding to residues 220-270 of human TIGAR.|
|Antigen affinity chromatography|
|Canine, Human, Non-human Primate|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.2% gelatin and 0.05% sodium azide|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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