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TIGAR Rabbit anti-Canine, Human, Non-human primate, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141487

Catalog No. 01-675-314


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Description

Description

TIGAR is a p53-inducible protein that functions to regulate glycolysis and protect against oxidative stress and is part of the p53 tumor suppressor pathway. It encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2, 6-bisphosphate. TIGAR functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Overexpression of TIGAR in mouse and human cells resulted in inhibition of glycolysis, as well as a decrease in intracellular reactive oxygen species (ROS) and provides some protection from DNA damage-induced apoptosis in a cell type-specific manner.
Specifications

Specifications

TIGAR
Polyclonal
Unconjugated
TIGAR
Liquid
TIGAR
Synthetic peptide corresponding to residues 220-270 of human TIGAR.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Canine, Human, Non-human Primate
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.2% gelatin and 0.05% sodium azide
Q9NQ88
TIGAR
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
486736, 57103
Documents
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