TIM-1 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520245
A suggested positive control is human uterus tissue lysate. PA5-20245 can be used with blocking peptide PEP-0364. The PA5-20245 immunogen is located within amino acids 230 - 280 of TIM-1. Predicted molecular ~ 44kD. In Western blot applications, this antibody has been observed to detect a band at: 60kD (Post-modification: 4 N-linked glycosylation) Predicted species reactivity based on immunogen sequence: Mouse: (50%), Rat: (44%)The human form of TIM-1 was initially discovered as a membrane glycoprotein through which the hepatitis A virus can gain entry into a cell. It was also identified as kidney injury molecule 1 (Kim-1), a predicted adhesion molecule that is upregulated on the surfaces of kidney epithelia. It is also expressed on T helper 2 (Th2) cells of the immune system, and following the binding of its natural ligand TIM-4, stimulates T cell expansion and cytokine production in response to viral challenge. It has been suggested that hyperactivation of TIM-1 leads to an increased level of Th2 responsiveness and asthma susceptibility, and antibodies to TIM-1 may therefore be a novel approach to treating asthma.
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|PBS with 0.02% sodium azide|
|A 16 amino acid peptide from near the center of human TIM-1.|
|Antigen affinity chromatography|
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