TIM-1 Mouse anti-Human, PE, Clone: 219211, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA523614
This antibody does not cross-react with recombit mouse (rm) TIM-1, rmTIM-2, or rhTIM-3.The human form of TIM-1 was initially discovered as a membrane glycoprotein through which the hepatitis A virus can gain entry into a cell. It was also identified as kidney injury molecule 1 (Kim-1), a predicted adhesion molecule that is upregulated on the surfaces of kidney epithelia. It is also expressed on T helper 2 (Th2) cells of the immune system, and following the binding of its natural ligand TIM-4, stimulates T cell expansion and cytokine production in response to viral challenge. It has been suggested that hyperactivation of TIM-1 leads to an increased level of Th2 responsiveness and asthma susceptibility, and antibodies to TIM-1 may therefore be a novel approach to treating asthma.
|Mouse myeloma cell line NS0-derived recombit human TIM-1/KIM-1/HAVCR Ser21-Thr288|
|Buffered saline solution with BSA and 0.09% sodium azide|
|HAVCR, HAVCR-1, KIM-1, KIM1, TIM-1, TIM1, TIMD1|
|4° C, store in dark, DO NOT FREEZE!|
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