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TIMD4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520247

Catalog No. PIPA520247


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Description

Description

A suggested positive control is Jurkat cell lysate. PA5-20247 can be used with blocking peptide PEP-0365.

The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors that are involved in the regulation of T helper (Th) -1 and -2 cell-mediated immunity. TIM-4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, and this binding leads to T-cell expansion and cytokine production. Unlike other members of the TIM family, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain. The TIM-4 gene maps to a locus associated with predisposition to asthma in both mice and humans and with its connection to TIM-1-triggered Th2 responsiveness, may be considered as a candidate disease/predisposition gene for asthma.
Specifications

Specifications

TIMD4
Polyclonal
Unconjugated
TIMD4
Liquid
TIMD4
A 15 amino acid peptide from near the carboxy terminus of human TIM-4.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q96H15, Q6U7R4
SMUCKLER, TIM4; T-cell immunoglobulin and mucin domain-containing protein 4; T-cell membrane protein 4; TIM-4; TIMD-4
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
276891, 497891, 91937
Documents
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