TIMELESS Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA528026
PA5-28026 targets TIMELESS in IF, IHC (P), and WB applications and shows reactivity with Human samples. The PA5-28026 immunogen is recombit fragment corresponding to a region within amino acids 1 and 384 of Human TIMELESS. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop. Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.
|Recombit fragment corresponding to a region within amino acids 1 and 384 of Human TIMELESS|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7|
|TIM, TIM1, hTIM, protein timeless homolog|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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