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anti-TIMP-3, Polyclonal, Novus Biologicals™

Rabbit Polyclonal Antibody

Manufacturer:  Novus BiologicalsSupplier Diversity Partner NBP233098

Catalog No. NBP233098


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Description

Description

TIMP-3 Polyclonal antibody specifically detects TIMP-3 in Human, Bovine, Canine, Equine, Sheep samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, CyTOF-ready.
Specifications

Specifications

TIMP-3
1.0 mg/mL
Western Blot, Flow Cytometry 0.5-1ug/million cells, Immunohistochemistry 0.5-1ug/ml, Immunocytochemistry/Immunofluorescence 1-2ug/ml, Immunoprecipitation 0.5-1ug/500ug protein lysate, Immunohistochemistry-Paraffin 0.5-1ug/ml, CyTOF-ready
Purified
TIMP3
A portion of amino acids 175-211 of human TIMP3 was used as immunogen for this antibody.
Protein A purified
RUO
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Polyclonal
TIMP3 (tissue inhibitor of metalloproteinases 3), along with family members TIMP1, TIMP2, and TIMP4, are inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix (ECM). An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. TIMP s inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes.
Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation
Unconjugated
10mM PBS - BSA free with No Preservative
HSMRK222, K222, K222TA2, metalloproteinase inhibitor 3, MIG-5 protein, Protein MIG-5, pseudoinflammatory), SFD, TIMP metallopeptidase inhibitor 3, TIMP-3, tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, Tissue inhibitor of metalloproteinases 3
Rabbit
IgG
0.1 mg
Angiogenesis, Apoptosis, Cancer, Hypoxia, Vision
Primary
7078
Human, Bovine, Canine, Equine, Sheep
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