TIMP1 Mouse anti-Human, Mouse, Rhesus Monkey, Clone: F31 P2 A5, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA1773
MA1-773 contains 100 µg of in vitro produced, protein A purified antibody (1 mg/mL) in PBS containing 1 mg/mL BSA and 0.05% sodium azide. MA1-773 detects TIMP-1 from human samples. MA1-773 has been successfully used in Western blot, immunofluorescence, and immunohistochemistry procedures. By Western blot, MA1-773 detects a ~30 kDa band representing TIMP-1 from K562 cell lysate. It is recommended to block with 3% BSA. The MA1-773 immunogen is a synthetic peptide corresponding to residues F(72) Q A L G D A A D I R(82) of mouse TIMP-1.This sequence is 100% conserved in some non-human primate TIMP-1.TIMP1 (metalloproteinase inhibitor 1) is a metalloproteinase inhibitor that functions by forms one-to-one complexes with target metallproteinases, such as collagenases, and irreversible inactivates them by binding to their catalytic zinc cofactor. TIMP1 acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP14, and MMP16. It also functions as a growth factor that regulates cell differenation, migration, and cell death. TIMP1 activates cellular signaling cascades via CD63 and ITGB1.
|PBS with 1mg/mL BSA and 0.05% sodium azide|
|P01033, P12032, Q95KL9|
|TIMP1, Tissue inhibitor of metalloproteinases 1, Erythroid-potentiating activity, EPA, Fibroblast collagenase inhibitor, Collagenase inhibitor|
|-20° C, Avoid Freeze/Thaw Cycles|
|21857, 574348, 7076|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|F31 P2 A5|
|Synthetic peptide corresponding to residues F(72) Q A L G D A A D I R(82) of mouse TIMP-1.|
|Human, Mouse, Rhesus Monkey|
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