TIRAP Mouse anti-Human, Clone: 20D1055.1, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA141198
Suggested positive control: human spleen.The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). TIRAP (TIR domain-containing adaptor protein) is an adaptor protein used by TLR4. Blocking TIRAP inhibits TLR4-mediated signaling events, including DC maturation and cytokine production (4). It has 235 amino acids and is commonly seen as a 32-37 kD protein (4).
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|ascites with 0.05% BSA and 0.05% sodium azide|
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