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TIRAP Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112815

Catalog No. 01-675-807


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Description

Description

A suggested positive control for this product is liver, kidney, spleen, skeletal muscle or heart lysate.

Toll-like receptors (TLRs) are evolutionarily conserved patternrecognition molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The signaling of these TLRs is kept under tight control by the expression of endogenous inhibiting proteins such as RP105, a recently identified homolog of TLR4. This protein, in association with MD-1, interacts with and inhibits the TLR4/MD-2 signaling pathway.. While MD-2 can directly bind to LPS, one of the activating molecules of TLR4, the function of MD -1 is less well-known. It has been suggested however, that the RP105/MD-1 complex influences antibody production mediated by both TLR4/MD-2 and TLR2 receptor complexes.
Specifications

Specifications

TIRAP
Polyclonal
PBS with 0.02% sodium azide
P58753, Q99JY1
Mal, wyatt
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
114609, 117149, 680127
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
TIRAP
Liquid
TIRAP
Synthetic peptide corresponding to 15 residues near the C-terminus of mouse TIRAP.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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