Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

TLR1 Mouse anti-Human, Biotin, Clone: GD2.F4, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA140169

Catalog No. 01-676-539


Add to cart

Description

Description

MA1-40169 detects TLR1 from human samples. MA1-40169 has been successfully used in flow cytometry applications. The MA1-40169 immunogen is human TLR1.

TLR1 protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. The Toll-like receptor (TLR) family in mammals are comprised of a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain. The TLRs could constitute an important and unrecognized component of innate immunity in humans. In mice, TLR1 interacts with TLR2 and co-expression of TLR1 and TLR2 enhance the NF-kappaB activation in response to a synthetic lipopeptide. They recognize the lipid configuration of the native mycobacterial lipoprotein as well as several tri-acylated lipopeptides. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for the TLR1 gene.
Specifications

Specifications

TLR1
Monoclonal
0.1 mg/mL
PBS with 0.1% BSA and 0.02% sodium azide
Q15399
Toll-like Receptor 1, TIL, TIL. LPRS5, rsc786, toll/interleukin-1 receptor-like protein
Mouse
IgG1
50 μg
4° C
Primary
7096
Flow Cytometry
GD2.F4
Biotin
TLR1
Liquid
TLR1
Human TLR1.
Purified
RUO
Antibody
Monoclonal
Human
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit