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TLR2 Rat anti-Mouse, Clone: 6C2, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA140048

Catalog No. 01-676-501


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Description

Description

MA1-40048 detects TLR2 from mouse samples. MA1-40048 has been successfully used in flow cytometry, immunoprecipitation, and immunofluorescence applications. The MA1-40048 immunogen is mouse TLR2/CD282.

TLR2 is a member of the Toll-like receptor (TLR) family which play a fundamental role in pathogen recognition and activation of innate immunity. TLR proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kappa-B. TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer, can recognize a variety of bacterial and mycoplasma lipoproteins respectively. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The various TLRs exhibit different patterns of expression. TLR2 is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. TLR2 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Ten human homologs of TLRs (TLR1-10) have been described. TLR2 is expressed in human cells such as tonsils, microglia, lymph nodes, and appendices, activated B-cells in germinal centers. CD14+ monocytes express the highest level of TLR2 followed by CD15+ granulocytes, CD19+ B-cells, and CD3+ T-cells. The expression of TLR2 on different cell types are regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes.
Specifications

Specifications

TLR2
Monoclonal
0.1 mg/mL
PBS with 0.1% BSA and 0.02% sodium azide
Q9QUN7
Toll-like Receptor 2, TIL4, toll/interleukin 1 receptor-like 4, toll/interleukin-1 receptor-like protein 4
Rat
IgG2b
100 μg
4° C
Primary
24088
Flow Cytometry, Immunofluorescence, Immunoprecipitation
6C2
Unconjugated
Tlr2
Liquid
TLR2
Murine TLR2/CD282.
Purified
RUO
Antibody
Monoclonal
Mouse
Documents
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