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TLR2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA511590

Catalog No. PIPA511590


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Description

Description

This antibody is predicted to react with non-human primate based on sequence homology.

TLR2 is a member of the Toll-like receptor (TLR) family which play a fundamental role in pathogen recognition and activation of innate immunity. TLR proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kappa-B. TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer, can recognize a variety of bacterial and mycoplasma lipoproteins respectively. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The various TLRs exhibit different patterns of expression. TLR2 is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. TLR2 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Ten human homologs of TLRs (TLR1-10) have been described. TLR2 is expressed in human cells such as tonsils, microglia, lymph nodes, and appendices, activated B-cells in germinal centers. CD14+ monocytes express the highest level of TLR2 followed by CD15+ granulocytes, CD19+ B-cells, and CD3+ T-cells. The expression of TLR2 on different cell types are regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes.
Specifications

Specifications

TLR2
Polyclonal
PBS with 0.09% sodium azide
O60603
Toll-like Receptor 2, TIL4, toll/interleukin 1 receptor-like 4, toll/interleukin-1 receptor-like protein 4
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
7097
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
TLR2
Liquid
TLR2
KLH conjugated synthetic peptide between 212-242 amino acids from the N-terminal region of human TLR2
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human
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