TLR4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™  

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen 482300

Catalog No. 48-230-0

Description

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain.

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Specifications

• Antigen: TLR4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TLR4
• Format: Liquid
• Gene Symbols: TLR4
• Immunogen: Synthetic peptide derived from the C-terminal region of the mouse TLR4 protein (AccessionNo. NP_067272, Q9QUK6), which is identical to rat and 94% homologous to human.
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Polyclonal
• Target Species: Human, Mouse, Rat

• Applications: Flow Cytometry, Immunoprecipitation, Western Blot
• Concentration: 0.25 mg/mL
• Formulation: PBS with 0.1% sodium azide; pH 7.4
• Gene Accession No.: O00206, Q9QUK6, Q9QX05
• Gene Alias: Toll-like Receptor 4, ARMD10, CD284, TLR-4, TOLL, hToll, homolog of Drosophila toll
• Host Species: Rabbit
• Isotype: IgG
• Quantity: 100 μg
• Storage Requirements: -20°C
• Primary or Secondary: Primary
• Gene ID (Entrez): 21898, 29260, 7099