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TLR4 Rabbit anti-Human, Non-human primate, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523270

Catalog No. PIPA523270


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Description

Description

TLR4 is an 839 amino acid member of the Toll-like receptor (TLR) family of transmembrane proteins comprised of multiple copies of leucine rich repeats in the extracellular domain and a TIR domain. It is a widely studied, phylogenetically conserved, member playing a fundamental role in pathogen recognition and activation of innate immunity. Like its counterpart in Drosophila, TLR4 signals through adaptor molecules and mediates the production of cytokines necessary for the development of effective immunity. TLR4 belongs to the multi-protein complex of lipopolysaccharide (LPS) receptor, containing CD14, LY96 and TLR4, and is involved in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. This receptor is most abundantly expressed in placenta, spleen and in myelomonocytic subpopulation of the leukocytes. Defects in this protein have been associated with differences in LPS responsiveness.
Specifications

Specifications

TLR4
Polyclonal
Unconjugated
TLR4
Liquid
TLR4
Synthetic peptide (666 KYGRGENIYDAF 677) of TLR4 protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Non-human Primate
Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
O00206
Toll-like Receptor 4, ARMD10, CD284, TLR-4, TOLL, hToll, homolog of Drosophila toll
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
7099
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