TLR4 Rabbit anti-Human, Non-human primate, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523270
DescriptionTLR4 is an 839 amino acid member of the Toll-like receptor (TLR) family of transmembrane proteins comprised of multiple copies of leucine rich repeats in the extracellular domain and a TIR domain. It is a widely studied, phylogenetically conserved, member playing a fundamental role in pathogen recognition and activation of innate immunity. Like its counterpart in Drosophila, TLR4 signals through adaptor molecules and mediates the production of cytokines necessary for the development of effective immunity. TLR4 belongs to the multi-protein complex of lipopolysaccharide (LPS) receptor, containing CD14, LY96 and TLR4, and is involved in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. This receptor is most abundantly expressed in placenta, spleen and in myelomonocytic subpopulation of the leukocytes. Defects in this protein have been associated with differences in LPS responsiveness.
|Synthetic peptide (666 KYGRGENIYDAF 677) of TLR4 protein.|
|Antigen affinity chromatography|
|Human, Non-human Primate|
|PBS with 0.05% BSA and 0.05% sodium azide|
|Toll-like Receptor 4, ARMD10, CD284, TLR-4, TOLL, hToll, homolog of Drosophila toll|
|-20° C, Avoid Freeze/Thaw Cycles|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok