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TLR7 Rabbit anti-Human, Mouse, FITC, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523489

Catalog No. PIPA523489


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Description

Description

TLR7 is a 1049 amino acid long highly conserved membrane protein belonging to the Toll-like receptor (TLR) family with 27 LRR (leucine-rich) repeats and a TIR domain. TLR7 plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 is activated by infections with single-stranded RNA viruses, including influenza virus and vesicular stomatitis virus (VSV). TLR7 is predomitly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8. TLR7 also acts via MyD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. TLR7 recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.
Specifications

Specifications

TLR7
Polyclonal
FITC
TLR7
Liquid
TLR7
Synthetic peptide (aa 684-700) of TLR7 protein.
Protein G
RUO
Antibody
Polyclonal
Human, Mouse
Flow Cytometry
0.88 mg/mL
50mM sodium borate with 0.05% sodium azide
Q9NYK1, P58681
UNQ248/PRO285
Rabbit
IgG
100 uL
4° C, store in dark
Primary
170743, 51284
Documents
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