TMEM88 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA521164
A suggested positive control is human brain tissue lysate. PA5-21164 can be used with blocking peptide PEP-1278.Transmembrane protein 88 (TMEM88) is a two-transmembrane-type protein whose C-terminal tail has been shown to bind the PDZ domain of Dishevelled (Dvl), one of the key components in Wnt signaling pathways. TMEM88 attentuated the Wnt/beta-catenin signaling induced by Wnt-1 ligand in a dose-dependent manner and knockdown of TMEM88 by RNAi increased Wnt activity, suggesting that TMEM88 plays a role in regulating Wnt signaling in a context-dependent manner.
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|497936, 67020, 92162|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|A 19 amino acid peptide near the carboxy terminus of human TMEM88.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
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