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TMP21 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520316

Catalog No. PIPA520316


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Description

Description

A suggested positive control is mouse brain tissue lysate. PA5-20316 can be used with blocking peptide PEP-0436.

TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the -gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the -gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer’s disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased -gamma-secretase activity but not epsilon-secretase activity, and increased Abeta; production, demonstrating that TMP21 can modulate -gamma-secretase activity.
Specifications

Specifications

TMP21
Polyclonal
Unconjugated
TMED10
Liquid
TMED10
An 18 amino acid peptide from near the center of human TMP21.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P49755, Q9D1D4, Q63584
P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I, p23; 21 kDa transmembrane trafficking protein; 21 kDa transmembrane-trafficking protein; p24 family protein delta-1; p24delta; p24delta1; transmembrane emp24 domain-containing protein 10; transmembrane protein Tmp21
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
10972, 68581, 84599
Documents
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