TMP21 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520316
A suggested positive control is mouse brain tissue lysate. PA5-20316 can be used with blocking peptide PEP-0436.TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the -gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the -gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer’s disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased -gamma-secretase activity but not epsilon-secretase activity, and increased Abeta; production, demonstrating that TMP21 can modulate -gamma-secretase activity.
|An 18 amino acid peptide from near the center of human TMP21.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|P49755, Q9D1D4, Q63584|
|P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I, p23; 21 kDa transmembrane trafficking protein; 21 kDa transmembrane-trafficking protein; p24 family protein delta-1; p24delta; p24delta1; transmembrane emp24 domain-containing protein 10; transmembrane protein Tmp21|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|10972, 68581, 84599|
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