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TNF alpha Mouse anti-Human, Clone: 28401, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523720

Catalog No. PIMA523720


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Description

Description

In sandwich ELISAs, less than 0.05% cross-reactivity with recombit human TNF- beta, recombit mouse TNF- alpha, recombit rat TNF- alpha, and recombit porcine TNF- alpha is observed. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
Specifications

Specifications

TNF Alpha
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
P01375
APC1 protein, TNF superfamily, member 2, TNF, macrophage-derived, TNF, monocyte-derived, TNF-a, cachectin, tumor necrosis factor alpha, tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha, TNFA
Mouse
IgG1
500 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
7124
ELISA, Immunocytochemistry, Immunofluorescence, Neutralization, Western Blot
28401
Unconjugated
TNF
Lyophilized
TNF
E. coli-derived recombit human TNF-alpha Gly57-Leu233 (predicted)
Protein A/G
RUO
Antibody
Monoclonal
Human
Documents
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