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TNF alpha Mouse anti-Human, Clone: 68B 2B3 A6 A2, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen AHC3912
Description
This product is recommended as a capture antibody in Sandwich ELISA applications. This clone can also be referred to as clone number 68B 2B3 A6 A2.
TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.This product(s) resides on a Fisher Scientific GSA or VA contract. If you are viewing this page as a nonregistered user, the price(s) displayed is List Price. To view your GSA or VA contract pricing, log in using your account number, or become a registered user by contacting one of our Customer Service teams. You can also view your contract price by searching for this item(s) on GSA Advantage. To place an order, contact Fisher Scientific Customer Service.
Specifications
TNF alpha | |
Monoclonal | |
1 mg/mL | |
PBS with 0.05% sodium azide; pH 7.5 | |
P01375 | |
APC1 protein, TNF superfamily, member 2, TNF, macrophage-derived, TNF, monocyte-derived, TNF-a, cachectin, tumor necrosis factor alpha, tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha, TNFA | |
Mouse | |
IgG2a | |
500 μg | |
4° C | |
Primary | |
7124 |
ELISA | |
68B 2B3 A6 A2 | |
Unconjugated | |
TNF | |
Liquid | |
TNF | |
Purified recombit human TNF-alpha. | |
Protein A | |
RUO | |
Antibody | |
Monoclonal | |
Human |
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