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TNF alpha Mouse anti-Human, Clone: 68B 6A3 1H8 1F2, Invitrogen™ Non-distribution product as customer accommodation. Available on GSA/VA Contract for Federal Government customers only.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen AHC3612

Catalog No. AHC3612


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Description

Description

This clone can also be referred to as clone number 68B 6A3 1H8 1F2.

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.

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Specifications

Specifications

TNF alpha
Monoclonal
1 mg/mL
PBS with 0.05% sodium azide; pH 7.5
P01375
APC1 protein, TNF superfamily, member 2, TNF, macrophage-derived, TNF, monocyte-derived, TNF-a, cachectin, tumor necrosis factor alpha, tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha, TNFA
Mouse
IgG1
500 μg
4° C
Primary
7124
Immunohistochemistry
68B 6A3 1H8 1F2
Unconjugated
TNF
Liquid
TNF
Recombit human TNF-alpha
Protein A
RUO
Antibody
Monoclonal
Human
SDS
Documents
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