Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

TNF alpha Rabbit anti-Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA140281

Catalog No. 01-676-400


Add to cart

Description

Description

Tumor Necrosis Factor-Alpha (TNF alpha) is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor-bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17kDa band following SDS-PAGE under non-reducing conditions. TNF alpha is closely related to the 25kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells.

PA1-40281 detects membrane and receptor bound TNF alpha from mouse and rat samples.PA1-40281 has been successfully used in flow cytometry, ELISA, functional assayas, immunohistochemistry (frozen), immunohistochemistry (paraffin), and Western blot applications. This antibody shows no neutralizing activity.The PA1-40281 imunogen is mouse TNF-alpha.
Specifications

Specifications

TNF alpha
Polyclonal
Unconjugated
Tnf
Liquid
TNF
Mouse TNF-alpha.
Purified
RUO
Antibody
Polyclonal
Mouse, Rat
ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
0.1 mg/mL
PBS with 0.1% BSA and no preservative
P06804, P16599
TNFA
Rabbit
IgG
100 μg
4° C
Primary
21926, 24835
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit