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TNFR1 Rat anti-Mouse, Clone: HM104, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA135667

Catalog No. 01-671-073


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Description

Description

TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily, and is one of the major TNF-alpha receptors. TNFR1 plays an important role in mediating, in cytokine mediated signaling, positive regulation of the NF-Kb pathway, positive regulation of angiogenesis, and negative regulation of gene expression. The extracellular domain of TNFR1 is also released into the circulatory system as soluble TNFR1 (sTNFR1). In humans, the TNFR1 gene is located on chromosome 12. Anti-apoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with TNFR1, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of TNFR1 were found to be associated with the autosomal domit periodic fever syndrome, and the impaired receptor clearance is thought to be a mechanism of the disease.
Specifications

Specifications

TNFR1
Monoclonal
0.1 mg/mL
PBS with 0.1% BSA and 0.02% sodium azide
P25118
CD120a, FPF, MGC19588, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR55, TNFR60, p55, p55-R, p60
Rat
IgG2a
100 μg
4° C
Primary
21937
ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation
HM104
Unconjugated
Tnfrsf1a
Liquid
TNFRSF1A
Proprietary immunogen.
Purified
RUO
Antibody
Monoclonal
Mouse
Documents
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