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TNFRSF14 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520237

Catalog No. PIPA520237


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Description

Description

A suggested positive control is mouse thymus tissue lysate. PA5-20237 can be used with blocking peptide PEP-0356.

Tumor necrosis factor receptor (TNFR) superfamily members are defined by cysteine-rich domains in their extracellular regions that bind TNF-related ligands that share a common structural homology in their extracellular domain. TNFRSF14 was initially identified as the Herpesvirus entry mediator and upon binding to the herpes simplex virus (HSV) envelope glycoprotein D or either of its natural ligands LIGHT and lymphotoxin alpha (LT), activates the transcription factors NF-kappa-B and AP-1. Activation of this signal transduction pathway in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses.
Specifications

Specifications

TNFRSF14
Polyclonal
Unconjugated
TNFRSF14
Liquid
TNFRSF14
A 15 amino acid peptide from near the amino terminus of human TNFRSF14.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q92956
RP3-395M20.6, ATAR, CD270, HVEA, HVEM, LIGHTR, TR2; CD40-like protein; herpes virus entry mediator A; herpesvirus entry mediator A; tumor necrosis factor receptor superfamily member 14; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator); tumor necrosis factor receptor-like 2; tumor necrosis factor receptor-like gene2
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
230979, 8764
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