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TNPO3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520551

Catalog No. PIPA520551


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Description

Description

A suggested positive control is rat liver tissue lysate. PA5-20551 can be used with blocking peptide PEP-0671.

TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.
Specifications

Specifications

TNPO3
Polyclonal
Unconjugated
TNPO3
Liquid
TNPO3
An 18 amino acid peptide from near the amino terminus of human TNPO3.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9Y5L0, Q6P2B1
IPO12, MTR10A, TRN-SR, TRN-SR2, TRNSR; imp12; importin 12; transportin-3; transportin-SR
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
23534, 296954, 320938
Documents
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