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Topo IIβ Mouse anti-Human, Unlabeled, Clone: 40, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611493

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Catalog No. BDB611493


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Description

Description

Eukaryotic DNA topoisomerase II, a ubiquitous ATP-dependent type II topoisomerase, is an essential nuclear enzyme in DNA replication and transcription, chromatin segregation, and cell cycle progression. Topoisomerases transiently break a pair of complementary strands in double-stranded DNA to form a gate for the passage of duplex DNA. Two isoforms of DNA topoisomerase II have been identified: topo IIα and topo IIβ. These exhibit a high degree of homology, except for some divergence in the C-terminal region. Both contain multiple bipartite nuclear localization sequences (NLS) that mediate their subnuclear localization. Topo IIα levels rise during late S phase and peak in G2-M, whereas topo IIβ levels remain constant throughout the cell cycle. In addition, topo IIα is expressed in proliferating cells, while topo IIβ is expressed in a wide range of tissues. Although the exact role of these two isoforms during cell proliferation is not known, the differences in cellular expression implicate different physiological roles. Both isoforms may also be important targets for anticancer agents that exert cytotoxicity in proliferating cells via stabilization of a topo II-DNA complex..

Host Species: Mouse
Clone: 40
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Topo IIβ aa. 1281-1494
Formula Weight [Chemical]: 180kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

Topo IIβ
40
Unconjugated
Affinity Purified
Human Topo IIβ aa. 1281-1494
150μg
Cell Biology
Primary
Human
In vitro Assay, Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Documents
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