TOP2A Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527248
PA5-27248 targets Topoisomerase II alpha in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-27248 immunogen is synthetic peptide corresponding to a region within amino acids 1415 and 1509 of Human Topoisomerase II alpha. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
|Synthetic peptide corresponding to a region within amino acids 1415 and 1509 of Human Topoisomerase II alpha|
|Antigen affinity chromatography|
|Immunohistochemistry (Paraffin), Western Blot|
|0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7|
|TOP2, TP2A, DNA gyrase, DNA topoisomerase (ATP-hydrolyzing), DNA topoisomerase 2-alpha, DNA topoisomerase II, 170 kD, DNA topoisomerase II, alpha isozyme|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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