TOP2B Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527750
PA5-27750 targets Topoisomerase II beta in IHC (P), IP, and WB applications and shows reactivity with Human samples. The PA5-27750 immunogen is recombit fragment corresponding to a region within amino acids 1448 and 1626 of Human Topoisomerase II beta. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described.
|Recombit fragment corresponding to a region within amino acids 1448 and 1626 of Human Topoisomerase II beta|
|Antigen affinity chromatography|
|Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|PBS with 1% BSA, 20% glycerol and 0.025% Proclin 300; pH 7|
|TOPIIB, top2beta, DNA topoisomerase 2-beta, DNA topoisomerase II beta, DNA topoisomerase II, 180 kD, DNA topoisomerase II, beta isozyme, U937 associated antigen, antigen MLAA-44, topo II beta, topoisomerase II beta, topoisomerase IIb|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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