FAIM3 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520285
Despite its predicted molecular weight, Toso often migrates at 60kDa in SDS-PAGE. A suggested positive control is human lung tissue lysate. PA5-20285 can be used with blocking peptide PEP-0403.Apoptosis is an important process by which normal tissue homeostasis and function are maintained. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas-associated death domain (FADD)- containing death-inducing signaling complex and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7. Recent experiments have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex.
|PBS with 0.02% sodium azide|
|FCMR, TOSO; Fc mu receptor; IgM Fc receptor; fas apoptotic inhibitory molecule 3; immunoglobulin mu Fc receptor; regulator of Fas-induced apoptosis Toso|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|A 13 amino acid peptide from near the carboxy terminus of human Toso.|
|Antigen affinity chromatography|
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