TPH2 Rabbit anti-Human, Mouse, Non-human primate, Rabbit, Rat, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA1778
PA1-778 detects TPH2 in human, mouse, rat, rabbit and non-human primate samples. PA1-778 has been successfully used in immunocytochemistry, immunoprecipitation, and Western blot procedures. By Western blot PA1-778 detects a 56 kDa protein representing TPH2. The PA1-778 immunogen is a synthetic peptide corresponding to the N-terminal region of TPH2.Tryptophan hydroxylase (TPH) catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin) (Martinez et al., 2001). In mammals, serotonin biosynthesis occurs predomitly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland. Although TPH catalyzes the same reaction within the Raphe nuclei and the pineal gland, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis. Serotonin functions mainly as a neurotransmitter, whereas melatonin is the principal hormone secreted by the pineal gland. The activity of TPH is enhanced by phosphorylation by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CaM K II) (Jiang et al., 2000; Johansen et al., 1996). CaM K II phosphorylates Ser260 which lies within the regulatory domain of TPH (Jiang et al., 2000).
|antibody with 1mg/mL BSA and 0.1% sodium azide|
|Q8IWU9, Q8CGV2, Q8CGU9|
|Tryptophan 5-hydroxylase 1, NTPH|
|100344397, 121278, 216343, 317675|
|Immunocytochemistry, Immunoprecipitation, Western Blot|
|Synthetic peptide corresponding to the N-terminal region of TPH2: R(15) R G L S L D S A V P E D H Q L (30)|
|Human, Mouse, Non-human primate, Rabbit, Rat|
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